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Brooks Women’s Glycerin GTS 21

Indulge in supreme softness with the Brooks Women’s Glycerin GTS 21. Featuring nitrogen-infused DNA LOFT v3 cushioning for pillowy comfort and the GuideRails® Support System for stability, this APMA-accepted shoe is perfect for runners who want it all. As an Amazon Associate, we earn from qualifying purchases.

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The Researcher’s Take: Why We Like It

If you believe there is no such thing as “too much cushioning” but you also need stability to keep your form in check, the Brooks Glycerin GTS 21 is your dream shoe.

Based on our analysis of the specs, this is the premium “Support” version of the famous Glycerin line. It takes the cloud-like feel of the nitrogen-infused DNA LOFT v3 midsole—Brooks’ softest foam—and pairs it with the GuideRails® system. In plain English, it feels like running on marshmallows, but with invisible guardrails that gently keep your knees and hips aligned when you get tired.

Key Features Breakdown

  • Supreme Softness: The midsole is packed with nitrogen-infused DNA LOFT v3 foam. It’s optimized to be lightweight, responsive, and durable, offering a plush, pillowy feel underfoot without feeling “dead” or heavy.
  • Smart Stability (GTS): The innovative GuideRails® holistic support system is there when you need it. It supports your body in its natural motion path while keeping excess movement (overpronation) in check, protecting your joints for the long haul.
  • Plush Fit: The new warp knit upper is breathable and flexible. Combined with a plush internal stretch bootie, it surrounds your foot in softness and expands with your stride for a custom-like fit.
  • Smooth Transitions: The broad platform stabilizes your foot upon landing and promotes a smooth, effortless transition from heel to toe.

Technical Specifications

  • Category: Stability / Max Cushion
  • Support Tech: GuideRails® System
  • Cushioning: DNA LOFT v3 (Nitrogen-infused)
  • Upper: Warp Knit with Internal Bootie
  • Certification: APMA Seal of Acceptance

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